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Factors Associated with Insulin Resistance in a Middle-Aged Non-Obese Rural Population: The Chungju Metabolic Disease Cohort (CMC) Study
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Sun Young Lim, Hee Sung Ha, Hyuk-Sang Kwon, Jin-Hee Lee, Hyeon Woo Yim, Kun-Ho Yoon, Won-Chul Lee, Ho-Young Son, Yong-Moon Park
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Epidemiol Health. 2011;33:e2011009. Published online September 26, 2011
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DOI: https://doi.org/10.4178/epih/e2011009
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Abstract
<sec><title>OBJECTIVES</title><p>We aimed to determine the characteristics affecting insulin resistance in non-obese middle-aged adults in a rural community.</p></sec><sec><title>METHODS</title><p>A total of 1,270 non-diabetic adults aged between 40 and 64 years old with body mass index (BMI) less than 25 kg/m<sup>2</sup> were analyzed. Subjects with insulin resistance were defined as those who had the highest quartile value of the homeostasis model assessment of insulin resistance (HOMA-IR) in a non-diabetic population.</p></sec><sec><title>RESULTS</title><p>A total of 217 subjects (20.6%) had insulin resistance. Prevalence of metabolic syndrome was significantly higher in insulin-resistant subjects in both men (29.3% vs. 10.3%) and women (34.1% vs. 15.6%). Among metabolic syndrome components, elevated waist circumference and elevated triglyceride were higher in insulin-resistant subjects in both genders. After being controlled for socioeconomic status and lifestyle related covariates, the association between insulin resistance and BMI was statistically significant in the category of 23.0-24.9 kg/m<sup>2</sup> in men (adjusted OR, 4.63; 95% confidence interval [95% CI], 1.77-12.15) using the category of 18.5-20.9 kg/m<sup>2</sup> as a reference. In addition, the association between insulin resistance and abdominal obesity was statistically significant only for men (adjusted OR, 2.57; 95% CI, 1.29-5.11).</p></sec><sec><title>CONCLUSION</title><p>Insulin resistance appears to be highly associated with high BMI and abdominal obesity, even in non-obese, non-diabetic middle-aged men.</p></sec>
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